In addition to inspection of the solution [see Dosage and Administration (2.2, 2.3)], the infusion set and catheter should also periodically be checked for precipitates. Selenium is present in human milk. 2.1 Important Administration Information Selenious Acid Injection is supplied as a … EC number: 231-974-7 | CAS number: 7783-00-8 . See full prescribing information for SELENIOUS ACID INJECTION. Selenious Acid Injection is indicated in adult and pediatric patients as a source of selenium for parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated. Hydrogen selenide acts as a selenium pool to form selenoproteins which include, but are not limited to, glutathione peroxidase, iodothyronine deiodinase, peroxidase and thioredoxins. Selenious acid is converted in vivo to hydrogen selenide via glutathione-involved electron reductions. The infusion of hypertonic nutrient injections into a peripheral vein may result in vein irritation, vein damage, and/or thrombosis. Selenious Acid Injection is indicated in adult and pediatric patients as a source of selenium for parenteral nutrition (PN) when oral or enteral nutrition is not possible, insufficient, or contraindicated. Reported clinical experience with intravenous selenious acid has not identified a difference in selenium requirements between elderly and younger patients. Selenious Acid Injection is approved for use in the pediatric population, including neonates, as a source of selenium for parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated. 10/2020, 600 mcg*/10 mL(60 mcg*/mL) of selenium Store at 20°C to 25°C (68°F to 77°F) [see USP Controlled Room Temperature]. 10 mL PHARMACY BULK PACKAGE, NDC 0517-6560-05 The pH range is 1.8 to 2.4; pH may be adjusted with Nitric Acid. The pH range is 1.8 to 2.4; pH may be adjusted with Nitric Acid. It is not for direct intravenous infusion. 10/2020, 600 mcg*/10 mL Selenium acid is a white hygroscopic solid that has a hexagonal crystal structure. There is no information on the effects of selenious acid on milk production. The new selenium presentation is a 60 mcg/mL 10 mL vial. 25 x 10 mL VIALS PHARMACY BULK PACKAGE Pharmacy Bulk Package. It contains not less than 95.0 percent and not more than 105.0 percent of the labeled amount of selenium (Se). Important Administration Information. It is not for direct intravenous infusion. The dosages in the following table are general recommendations intended for most patients. Selenious Acid Injection is supplied as a pharmacy bulk package for admixing use only. Separation of the emulsion can be visibly identified by a yellowish streaking of the accumulation of yellowish droplets in the admixed emulsion. Preterm infants are particularly at risk for aluminum toxicity because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which also contain aluminum. Deficiency of trace elements, including selenium, is associated with adverse pregnancy and fetal outcomes. For storage of admixed solution, see Dosage and Administration (2.3). Selenious Acid Injection is supplied as a pharmacy bulk package for admixing use only. Severe hy contractilityfrom a toxic cardiomyopathyand to inappropriatelylow peri include thrombocytopenia,moderate hepatorenal dysfunction, and elevated, To … Other signs include gastrointestinal disturbances, skin rash, garlic breath, fatigue, irritability, and nervous system abnormalities including paresthesia and ataxia. Each Pharmacy Bulk Package vial contains 10 mL of selenious acid solution and does not contain preservatives. Not for direct intravenous infusion. Use Selenious Acid Injection for admixing promptly once the sterile transfer set has been inserted into the Pharmacy Bulk Package container or not more than 4 hours at room temperature (25ºC/77ºF) after the container closure has been penetrated. Important Administration Information . If it is deemed advisable to introduce additives to the parenteral nutrition container, use aseptic technique. Selenious Acid Injection is a sterile solution in Water for C S, in µg/mL, of selenium in the Sample solution. (5.3, 5.4), Monitoring and Laboratory Tests:  Monitor selenium concentrations, fluid and electrolyte status, serum osmolarity, blood glucose, liver and kidney function, blood count and coagulation parameters throughout treatment. Serious adverse events and deaths have been reported with acute oral toxicity, however, there is no clear correlation between the amount ingested, signs and symptoms of toxicity, or selenium blood concentrations. The primary complication of peripheral access is venous thrombophlebitis, which manifests as pain, erythema, tenderness or a palpable cord. 25 x 10 mL VIALS The key factor in the preparation is careful aseptic technique to avoid inadvertent touch contamination during mixing of solutions and addition of other nutrients. Selenium injection is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Prior to administration, Selenious Acid Injectionmust be transferred to a separate parenteral nutrition container, prepared and used as an admixture in parenteral nutrition solutions. For intravenous use after dilution and admixing Aggressive dilution with water or saline is indicated after topical exposure to selenious acid. Consult with pharmacist, if available. Any storage of the admixture should be under refrigeration from 2°C to 8°C (36°F to 46°F) and limited to a period of time no longer than 9 days. Remove the catheter as soon as possible, if thrombophlebitis develops. Serious adverse events and deaths have been reported with acute oral toxicity, however, there is no clear correlation between the amount ingested, signs and symptoms of toxicity, or selenium blood concentrations. The estimated oral bioavailability of selenium is approximately 70%. The primary complication of peripheral access is venous thrombophlebitis, which manifests as pain, erythema, tenderness or a palpable cord. Selenious Acid Injection is approved for use in the pediatric population, including neonates, as a source of selenium for parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated. Medically reviewed by Drugs.com. n the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively. The cause of precipitate formation has not been determined in all cases; however, in some fatal cases, pulmonary emboli occurred as a result of calcium phosphate precipitates. Inspect Selenious Acid Injection Bulk Pharmacy Package for particulate matter. Death from circulatory collapse has been reported after oral ingestion of 5 to 10 grams of selenium. Other signs include gastrointestinal disturbances, skin rash, garlic breath, fatigue, irritability, and nervous system abnormalities including paresthesia and ataxia.

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